Cushing's Disease (Hyperadrenocorticism, PDH)

One large capsule per 10 - 20 lbs twice daily, dependent on severity.

Diosocorea, trichosanthes root, moutan, lycium fruit, lycium bark, rehmania, scrophularia, asparagus, ophiopogon, mume, anemarrhena, gypsum, schizandra, cornus, mantis egg case.

Adjust the dose as needed according to clinical response. In general the clinical signs, i.e. polydipsia/ polyuria, panting and pot bellied appearance begin to resolve first. Liver enzymes (alkaline phosphatase, ALT) then tend to drop. In most, but not all animals cortisol levels should normalize. Monitoring is by blood panel, UA, ACTH stimulation test or LDDST. Typically, patients will show clinical improvement within the first 2-3 weeks, such as lessening PU/PD/PP. some may take up to 4-5 weeks. ALT & Alk Phosphate will drop in 4-8 weeks, LDDST or ACTH stimulation test back to normal in 1-3 months.

Do not use in animals sensitive to any of the ingredients.

Prescribing Information:
Warning: Do not use in conjunction with Lysodren, Ketaconazole or Trilostaine. It’s recommended to discontinue these drugs and initiated Adrenosol simultaneously. This formula is not intended for adrenal tumor induced Cushing’s disease. Toxicity & reactions are extremely rare. In some extreme cases, herbal supplements may cause vomiting & diarrhea in the first 24-48 hours. Symptoms stop as soon as the herbal supplements discontinued.


Use caution when using with lysodren or ketoconazole. If either drug has been administered, discontinue the medications for 24 hours before initiating adrenosol. Combination with either lysodren or ketoconazole may precipitate an Addisonian crisis. If this does occur, discontinue medications and the supplement and treat as usual for hypoadrenocorticism.